참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Pyridine, 3-(2-chloroethyl)-, hydrochloride | HCID 199465 | — |
| 생성물 | N-Methyl-2-(pyridin-3-YL)ethanamine | HCID 5152594 | 110.5% |
반응 단계
To 32.6 g of 40% aqueous methylamine solution was added 7.48 g (0.042 mole) of 2-(3-pyridyl)ethyl chloride hydrochloride in small portions with stirring. The mixture was transfered to a stainless steel reaction column and heated at an external temperature of 80° C. for 4 hours. After cooling, 3.36 g of NaOH was added with ice-cooling and stirring and the mixture was saturated with sodium chloride and extracted with CH2Cl2. The extract was dried over MgSO4 and the CH2Cl2 was distilled off to give 6.32 g of the title compound in crude form as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05214152 |
|---|
| 출처 데이터셋 | uspto-grants-1993_05 |
|---|
| ORD ID | ord-dbb7fe6b4f0c445f834aa9bd274f8366 |
|---|
| 출처 메모 | uspto-grants-1993_05 |
|---|
