反应详情

In 100 ml of EtOH was dissolved 1.2 g (4.6×10-3 mole) of 1-(6-chloro-3-pyridylmethyl)amino-1-methylthio-2-nitroethylene and on reflux, a solution of 0.84 g of 40% aqueous methylamine in 30 ml EtOH was added dropwise over 1 hour. After cooling, the reaction mixture was concentrated under reduced pressure to about 50 ml and the resulting crystals were collected by filtration and dried to give 0.6 g of the title compound as pale yellow needles.

1. temperatureon reflux
2. temperatureAfter cooling
3. concentrationthe reaction mixture was concentrated under reduced pressure to about 50 ml
4. filtrationthe resulting crystals were collected by filtration
5. customdried