反应详情

In 35 ml of toluene, 3,79 g (0.0169 mole) of N-(6-chloro-3-pyridylmethyl)-N-(2,2,2-trifluoroethyl)amine and 2.46 g of methyl isothiocyanate were stirred for 18 hours under reflux. The toluene was distilled off, and the residue was dissolved in 120 ml of AcOEt, washed with 1N HCl (two times) and aqueous sodium chloride solution in this order and dried over MgSO4. The AcOEt was distilled off to give oil. To this oily product were added Et2O and hexane, followed by cooling to give crystals. After addition of hexane to the mixture, the crystals were collected by filtration and dried to give 2.78 g of N-(6-chloro-3-pyridylmethyl)-N-(2,2,2-trifluoroethyl)-N'-methylthiourea as white crystals.

1. temperatureunder reflux
2. distillationThe toluene was distilled off
3. dissolutionthe residue was dissolved in 120 ml of AcOEt
4. washwashed with 1N HCl (two times) and aqueous sodium chloride solution in this order
5. dry with materialdried over MgSO4
6. distillationThe AcOEt was distilled off
7. customto give oil
8. temperatureby cooling
9. customto give crystals
10. filtrationthe crystals were collected by filtration
11. customdried