Sodium Iodide → HCID 10037978, compound

HRID 249585Notes

Reaction equation

HRID 249585 reaction equation
Cl[CH2:2][S:3][C:4]1[N:5]([CH3:9])[N:6]=[CH:7][N:8]=1.[I-:10].[Na+]>CC(C)=O.O>[I:10][CH2:2][S:3][C:4]1[N:5]([CH3:9])[N:6]=[CH:7][N:8]=1

Participants

5

Reactant 2

HCID 5238Sodium IodideHCID 10012233HCID 10012233, compound

Product 1

HCID 10037978HCID 10037978, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 3-chloromethylthio-2-methyl-1,2,4-triazole (981 mg : 6.0 mMol.) in acetone (10 ml) is added sodium iodide (1.78 g : 12.0 mMol.), and the mixture is stirred at 50° C. for 3 hours. The reaction mixture is diluted with water and extracted with ethyl acetate. The extract is washed with water, dried over sodium sulfate, and concentrated to give 3-iodomethylthio-2-methyl-1,2,4triazole (1.47 g) as yellow oil.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract is washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-dbd8ef55805f4807b68658bbb492f5cb
Source dataset
uspto-grants-1993_05
Patent number
US05214037

Reaction notes

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