反应详情

温度

50 °C

To a solution of 5-chloromethylthio-1-methyltetrazole (987 mg:6.0 mMol.) in acetone (10 ml) is added sodium iodide (1.78 g : 12.0 mMol.), and the mixture is stirred at 50° C. for 3 hours. After cooling, the reaction mixture is diluted with water and extracted with ethyl acetate. The extract is washed with water dried over sodium sulfate, filtered, and concentrated to give 5-iodomethylthio-1-methyltetrazole as yellow oil (1.33 g : containing about 20 Mol. % of the chloride).

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. washThe extract is washed with water
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated