反应详情

温度

-27 °C

To a solution of 4-chloroacetoacetic acid methyl ester (700 mg : 4.65 mMol.) and propionaldehyde (405 mg : 6.97 mMol.) and acetic acid (28 mg : 0.47 mMol.) in dichloromethane (3 ml) is added a solution of piperidine (24 mg : 0.28 mMol.) in dichloromethane (0.5 ml), and the mixture is stirred at -27° C. for 120 minutes. The reaction mixture is washed with dilute hydrochloric acid and water and concentrated under reduced pressure at lower than 15° C. to give 4-chloro-2-propylideneacetoacetic acid methyl ester (818 mg). Yield: 92%.

1. washThe reaction mixture is washed with dilute hydrochloric acid and water
2. concentrationconcentrated under reduced pressure at lower than 15° C.