反应详情

温度

104 °C

2-Acetylpyridine (48.28 g, 0.398 mole) and N,N-Dimethylformamide dimethyl acetal (95 g. 0.797 mole) were added to a flask. The reaction mixture was heated to 104° C. for 15 hours. The excess N,N-Dimethylformamide dimethyl acetal was evaporated off. The residue was recrystallized from a mixture of toluene (140 mL.) and heptane (955 mL.) to give 1-(2-pyridyl)-3-dimethylamino-2-propen-1-one (58.7 g, 70% yield).

1. customThe excess N,N-Dimethylformamide dimethyl acetal was evaporated off
2. customThe residue was recrystallized from a mixture of toluene (140 mL.) and heptane (955 mL.)