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Dry ethanol (600 mL), 91.89 g of guanidine carbonate, and 146.1 g of ethyl acetoacetate were added to a 1 L flask. The reaction solution was gradually heated to reflux temperature and stirred overnight. Ethanol (300 mL) was evaporated, and the reaction mixture was heated under reflux for two hours. After the reaction mixture was cooled, 300 mL of hexane was added. The resulting precipitate was filtered, washed and dried. 119.3 g of 6-methyl-iso cytosine was obtained.

1. temperatureThe reaction solution was gradually heated
2. temperatureto reflux temperature
3. customEthanol (300 mL) was evaporated
4. temperaturethe reaction mixture was heated
5. temperatureunder reflux for two hours
6. temperatureAfter the reaction mixture was cooled
7. addition300 mL of hexane was added
8. filtrationThe resulting precipitate was filtered
9. washwashed
10. customdried