Phenylhydrazine → HCID 178515218, compound

HRID 249677Notes

Reaction equation

HRID 249677 reaction equation
[C:1]1([N:7]2C(=O)C3=CNC4C=CC=CC=4C3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][C:28]([F:33])=[C:29]([F:32])[CH:30]=2)[N:25]=[CH:24][C:23]=1[C:34]([O:36]CC)=O.C1(NN)C=CC=CC=1>>[F:33][C:28]1[C:29]([F:32])=[CH:30][C:31]2[C:22]3[C:23]([C:34](=[O:36])[N:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[N:8]=3)=[CH:24][NH:25][C:26]=2[CH:27]=1

Participants

4

Reactant 3

HCID 7516PhenylhydrazineHCID 1511944Ethyl 4-chloro-6,7-difluoroquinoline-3-carboxylateHCID 178515184HCID 178515184, compound

Product 1

HCID 178515218HCID 178515218, compound

Procedure

The title compound was prepared following the procedure described in Step 3 for the synthesis of 4a, using 3c and phenyl hydrazine. 1H NMR (DMSO-d6) δ (ppm): 7.18 (1H, t, J=7.82 Hz), 7.43 (2H, dd, J=8.30, 7.33 Hz), 7.75 (1H, dd, J=11.22, 7.32 Hz), 8.18, 3H, m), 8.90 (1H, s). m/z 298.2 (MH+).

Sources & evidence

ORD record
ord-d1d780ae30f24fec9ae1d8c93ea47bf8
Source dataset
uspto-grants-2011_01
Patent number
US07863266B2

Reaction notes

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