反应详情

6-Cyanonicotinic acid as the trifluoroacetate (1 g) was dissolved in methanol (300 ml), treated with Raney nickel (0.224 g) and hydrogenated in a shaker autoclave at 80° C. for 20 h under 10 bar hydrogen pressure. Subsequently, the mixture was filtered, the residue was washed with a water/methanol mixture and the filtrate was concentrated. The residue was taken up with ACN/water and freeze-dried. 500 mg of product were obtained, which were sufficiently clean for use in the next stage.

1. filtrationSubsequently, the mixture was filtered
2. washthe residue was washed with a water/methanol mixture
3. concentrationthe filtrate was concentrated
4. customfreeze-dried