Trifluoroacetate → 6-Aminomethylnicotinic acid trifluoroacetate

Participants

Reaction Steps

6-Cyanonicotinic acid as the trifluoroacetate (1 g) was dissolved in methanol (300 ml), treated with Raney nickel (0.224 g) and hydrogenated in a shaker autoclave at 80° C. for 20 h under 10 bar hydrogen pressure. Subsequently, the mixture was filtered, the residue was washed with a water/methanol mixture and the filtrate was concentrated. The residue was taken up with ACN/water and freeze-dried. 500 mg of product were obtained, which were sufficiently clean for use in the next stage.

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