Ethanol → HCID 57791288, compound

HRID 249717Notes

Reaction equation

HRID 249717 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:6][N:5]=[C:4]([CH3:12])[CH:3]=1.[CH2:13]([OH:15])[CH3:14].[O-]CC.[Na+]>O>[CH2:13]([O:15][C:2]1[C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:6][N:5]=[C:4]([CH3:12])[CH:3]=1)[CH3:14]

Participants

5

Reactant 3

HCID 702EthanolHCID 2723922Sodium ethoxideHCID 21904684HCID 21904684, compound

Product 1

HCID 57791288HCID 57791288, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-Chloro-6,N-dimethylnicotinamide (2.4 g) was dissolved with stirring in abs. ethanol (40 ml) and treated with sodium ethoxide (1.8 g). After stirring at RT for 4 h, the mixture was allowed to stand overnight. After addition of water, it was extracted 3 times with DCM. The combined organic phases were dried over sodium sulfate, filtered and concentrated. 2.2 g of the desired compound were obtained.

Workup

  1. stirringAfter stirring at RT for 4 h
  2. extractionwas extracted 3 times with DCM
  3. dry with materialThe combined organic phases were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-658ca45220454523a9179a350eb18759
Source dataset
uspto-grants-2011_01
Patent number
US07863269B2

Reaction notes

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