HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 178469038, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 6-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid | HCID 178427244 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 178469038 | HCID 178469038 | — |
Reaction Steps
20.0 g (130.6 mmol) of 2-hydroxy-6-methylisonicotinic acid were dissolved in 200 ml of ethanol and treated with 20 ml of concentrated H2SO4. After the reaction mixture had been refluxed for two hours, it was freed from the solvent. The residue was taken up in saturated NaHCO3 solution and extracted three times with DCM. The combined organic phases were dried with Na2SO4 and concentrated, 20.1 g of the title compound being isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863269B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-1689bbf0d5984fc699c285d9a9a10ff0 |
| Source note | uspto-grants-2011_01 |