反应详情

20.0 g (130.6 mmol) of 2-hydroxy-6-methylisonicotinic acid were dissolved in 200 ml of ethanol and treated with 20 ml of concentrated H2SO4. After the reaction mixture had been refluxed for two hours, it was freed from the solvent. The residue was taken up in saturated NaHCO3 solution and extracted three times with DCM. The combined organic phases were dried with Na2SO4 and concentrated, 20.1 g of the title compound being isolated.

1. temperatureAfter the reaction mixture had been refluxed for two hours
2. extractionextracted three times with DCM
3. dry with materialThe combined organic phases were dried with Na2SO4
4. concentrationconcentrated