Ethylorthoformate → HCID 135846125, compound

HRID 249759Notes

Reaction equation

HRID 249759 reaction equation
[CH2:1]([N:6]1[C:14]2[N:13]=[C:12]([C:15]([F:18])([F:17])[F:16])[NH:11][C:10]=2/[C:9](=[N:19]\[NH2:20])/[NH:8][C:7]1=[O:21])[CH2:2][CH2:3][CH2:4][CH3:5].[CH:22]([O-])([O-])OCC>>[CH2:1]([N:6]1[C:14]2[N:13]=[C:12]([C:15]([F:16])([F:18])[F:17])[NH:11][C:10]=2[C:9]2=[N:19][N:20]=[CH:22][N:8]2[C:7]1=[O:21])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 53630039EthylorthoformateHCID 178446231HCID 178446231, compound

Product 1

HCID 135846125HCID 135846125, compound

Conditions

Temperature
100 °C

Procedure

(6E)-3-Pentyl-8-(trifluoromethyl)-3,7-dihydro-1H-purine-2,6-dione-6-hydrazone (0.15 g, 0.20 mmol) was mixed with ethyl orthoformate (2 mL, 10 mmol). The mixture was heated at 100° C. for 30 min, concentrated under reduced pressure and purified by preparative HPLC to yield the desired product. LCMS calculated for C12H14F3N6O (M+H): 315.1. found: 315.1.

Workup

  1. concentrationconcentrated under reduced pressure
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-b3d72c81be584af181b8ab31d6cf459c
Source dataset
uspto-grants-2011_01
Patent number
US07863285B2

Reaction notes

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