(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → HCID 66873775, compound

HRID 249842Notes

Reaction equation

HRID 249842 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[O:9][C:10]3[C:11](=[C:13]([C:17]([OH:19])=O)[CH:14]=[CH:15][CH:16]=3)[N:12]=2)=[CH:3][CH:2]=1.Cl.Cl.[NH2:22][C@H:23]1[CH:28]2[CH2:29][CH2:30][N:25]([CH2:26][CH2:27]2)[CH2:24]1>>[N:25]12[CH2:24][C@@H:23]([NH:22][C:17]([C:13]3[CH:14]=[CH:15][CH:16]=[C:10]4[O:9][C:8]([NH:7][C:4]5[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=5)=[N:12][C:11]=34)=[O:19])[CH:28]([CH2:29][CH2:30]1)[CH2:27][CH2:26]2

Participants

3

Reactant 2

HCID 12494973(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochlorideHCID 66873324HCID 66873324, compound

Product 1

HCID 66873775HCID 66873775, compound

Procedure

Following general procedure GP-C1, a mixture of 2-(pyridin-4-ylamino)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(pyridin-4-ylamino)benzoxazole-4-carboxamide, which was converted to the dihydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

Sources & evidence

ORD record
ord-a0a680c7f71f4cbf8f5820a6d796aa77
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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