Lithium iodide → HCID 66874898, compound

HRID 249889Notes

Reaction equation

HRID 249889 reaction equation
[Li+:1].[I-].[Si:3]([O:10][CH2:11][C@@H:12]1[N:17]([C:18]2[O:19][C:20]3[C:21](=[C:23]([C:27]([O:29]C)=[O:28])[CH:24]=[CH:25][CH:26]=3)[N:22]=2)[CH2:16][CH2:15][O:14][CH2:13]1)([C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:5])[CH3:4]>N1C=CC=CC=1>[Si:3]([O:10][CH2:11][C@@H:12]1[N:17]([C:18]2[O:19][C:20]3[C:21](=[C:23]([C:27]([O-:29])=[O:28])[CH:24]=[CH:25][CH:26]=3)[N:22]=2)[CH2:16][CH2:15][O:14][CH2:13]1)([C:6]([CH3:7])([CH3:8])[CH3:9])([CH3:4])[CH3:5].[Li+:1]

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 66874698HCID 66874698, compound

Product 1

HCID 66874898HCID 66874898, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of LiI (298 mg, 2.22 mmol) in refluxing anhydrous pyridine (50 mL) was added (R)-methyl 2-(3-((tert-butyldimethylsilyloxy)methyl)morpholino)benzoxazole-4-carboxylate (226 mg, 0.55 mmol) and the reaction mixture was refluxed for 24 h. The mixture was cooled to room temperature, concentrated to dryness and dried in vacuum to provide lithium (R)-2-(3-((tert-butyldimethylsilyloxy)methyl)morpholino)benzoxazole-4-carboxylate as a yellow oil which was used without further purification. MS consistent.

Workup

  1. temperaturethe reaction mixture was refluxed for 24 h
  2. concentrationconcentrated to dryness
  3. customdried in vacuum

Sources & evidence

ORD record
ord-ab0989cfa6914ea0bfdd50abfb4eb5ce
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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