8-methyl-8-azabicyclo[3.2.1]octan-3-amine Dihydrochloride → 1,3-Benzoxazole-4-carboxamide

HRID 249897Notes

Reaction equation

HRID 249897 reaction equation
C[C@@H]1N([C:8]2[O:9][C:10]3[C:11](=[C:13]([C:17]([OH:19])=O)[CH:14]=[CH:15][CH:16]=3)[N:12]=2)[C@@H](C)COC1.Cl.Cl.C[N:24]1C2CCC1CC(N)C2>>[O:9]1[C:10]2=[CH:16][CH:15]=[CH:14][C:13]([C:17]([NH2:24])=[O:19])=[C:11]2[N:12]=[CH:8]1

Participants

3

Reactant 2

HCID 27759288-methyl-8-azabicyclo[3.2.1]octan-3-amine DihydrochlorideHCID 668735122-((3S,5S)-3,5-dimethylmorpholino)benzoxazole-4-carboxylic acid

Product 1

HCID 183694961,3-Benzoxazole-4-carboxamide

Procedure

Following general procedure GP-C1, a mixture of 2-((3S,5S)-3,5-dimethylmorpholino)benzoxazole-4-carboxylic acid and 8-methyl-8-azabicyclo[3.2.1]octan-3-amine dihydrochloride were coupled to provide N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(3 S,5S)-3,5-dimethylmorpholino)benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

Sources & evidence

ORD record
ord-f6d7bf6d8df44da2b8aeff58c33e0603
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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