HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-methyl-8-azabicyclo[3.2.1]octan-3-amine Dihydrochloride → 1,3-Benzoxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-methyl-8-azabicyclo[3.2.1]octan-3-amine Dihydrochloride | HCID 2775928 | — |
| Reactant | 2-((3S,5S)-3,5-dimethylmorpholino)benzoxazole-4-carboxylic acid | HCID 66873512 | — |
| Product | 1,3-Benzoxazole-4-carboxamide | HCID 18369496 | — |
Reaction Steps
Following general procedure GP-C1, a mixture of 2-((3S,5S)-3,5-dimethylmorpholino)benzoxazole-4-carboxylic acid and 8-methyl-8-azabicyclo[3.2.1]octan-3-amine dihydrochloride were coupled to provide N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(3 S,5S)-3,5-dimethylmorpholino)benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863271B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-f6d7bf6d8df44da2b8aeff58c33e0603 |
| Source note | uspto-grants-2011_01 |