反应详情

To a solution of methyl 2-amino-3-methoxybenzoate (13.0 g, 71.8 mmol) in DMF (30 mL) was added NBS (14.38 g, 80.8 mmol) at room temperature and the resulting reaction mixture was stirred for 17 h. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by column chromatography (silica gel, 2% to 5% EtOAc in hexanes) to afford methyl 2-amino-5-bromo-3-methoxybenzoate (13.7 g, 73%). 1H NMR consistent.

1. customthe resulting reaction mixture
2. filtrationThe reaction mixture was filtered through Celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe resulting residue was purified by column chromatography (silica gel, 2% to 5% EtOAc in hexanes)