反应详情

温度

100 °C

To the oil of non-polydispersed tetraethylene glycol (19.4 g, 0.10 mol) was added a solution of NaOH (4.0 in 4.0 mL) and the reaction was stirred for 15 min. Then benzyl chloride (3.54 mL, 30.8 mmol) was added and the reaction mixture was heated to 100° C. and stirred overnight. The reaction mixture was cooled to room temperature, diluted with sat. NaCl (250 mL), and washed CH2Cl2 (2×200 mL). The organic layers were combined, washed sat. NaCl, dried MgSO4, and chromatographed (silica, ethyl acetate) to afford the non-polydispersed title compound as a yellow oil (6.21 g, 71% yield).

1. stirringstirred overnight
2. temperatureThe reaction mixture was cooled to room temperature
3. washwashed CH2Cl2 (2×200 mL)
4. washwashed sat. NaCl, dried MgSO4
5. customchromatographed (silica, ethyl acetate)