Dichloromethane methanol → HCID 57788028, compound

HRID 249946Notes

Reaction equation

HRID 249946 reaction equation
[CH:1]1([NH:5][C:6]2[C:15]3[C:10](=[CH:11][C:12]([O:18][CH2:19][C:20]4[CH:21]=[C:22]([S:26]([CH2:34][CH3:35])(=[N:28]C(OCC)=O)=[O:27])[CH:23]=[CH:24][CH:25]=4)=[C:13]([O:16][CH3:17])[CH:14]=3)[N:9]=[CH:8][N:7]=2)[CH2:4][CH2:3][CH2:2]1.ClCCl.CO>CO>[CH:1]1([NH:5][C:6]2[C:15]3[C:10](=[CH:11][C:12]([O:18][CH2:19][C:20]4[CH:21]=[C:22]([S:26]([CH2:34][CH3:35])(=[NH:28])=[O:27])[CH:23]=[CH:24][CH:25]=4)=[C:13]([O:16][CH3:17])[CH:14]=3)[N:9]=[CH:8][N:7]=2)[CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 21226129Dichloromethane methanolHCID 57788012HCID 57788012, compound

Product 1

HCID 57788028HCID 57788028, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to GWP 6, the conversion of (RS)-S-[3-({[4-(cyclobutylamino)-6-methoxy-quinazolin-7-yl]oxy}methyl)phenyl]-N-(ethoxycarbonyl)-S-ethylsulphoximide (48 mg, 0.096 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 94% yield (39 mg).

Sources & evidence

ORD record
ord-1b0afca3da5c465d911f858370d9d3e8
Source dataset
uspto-grants-2011_01
Patent number
US07863283B2

Reaction notes

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