HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane methanol → HCID 57788028, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 57788012 | HCID 57788012 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57788028 | HCID 57788028 | 94% |
Reaction Steps
According to GWP 6, the conversion of (RS)-S-[3-({[4-(cyclobutylamino)-6-methoxy-quinazolin-7-yl]oxy}methyl)phenyl]-N-(ethoxycarbonyl)-S-ethylsulphoximide (48 mg, 0.096 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 94% yield (39 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863283B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-1b0afca3da5c465d911f858370d9d3e8 |
| Source note | uspto-grants-2011_01 |