反应详情

温度

100 °C

To a solution of 100 g (0.655 mol) 2-(5-ethyl-pyridin-2-yl)-ethanol in 500 mL acetic acid was added 118 g (1.049 mol) 30% hydrogen peroxide at 25-30° C. Reaction mixture was refluxed at 100° C. (tlc) for 14 hr. After completion of the reaction acetic acid was removed under vacuum, and the residual mass was poured in excess water and made alkaline by 10% Na2CO3 solution. Product was extracted with ethyl acetate and after concentrating ethyl acetate in vacuo, 89.58 g (81%) crystalline product was obtained.

1. customReaction mixture
2. customwas removed under vacuum
3. additionthe residual mass was poured in excess water
4. extractionProduct was extracted with ethyl acetate
5. concentrationafter concentrating ethyl acetate in vacuo