HRID250183

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

HCID83572

1-Chloropinacolone

C6H11ClO

HCID6973630

(-)-Glycidol

C3H6O2

结构：CC(=O)N1CCC(c2ccc(O)c(C)c2)(c2ccc(OCC(=O)C(C)(C)C)c(C)c2)CC1

HCID66889593

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(=O)N1CCC(c2ccc(OCC(=O)C(C)(C)C)c(C)c2)(c2ccc(OCC(O)CO)c(C)c2)CC1

HCID66891091

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described for Example 6B, 1-{4-[1-acetyl-4-(4-hydroxy-3-methylphenyl)-piperidin-4-yl]-2-methylphenoxy)-3,3-dimethylbutan-2-one was prepared by using 1 equiv of 1-chloropinacolone and cesium carbonate. 1-{4-[1-Acetyl-4-(4-hydroxy-3-methylphenyl)-piperidin-4-yl]-2-methylphenoxy}-3,3-dimethylbutan-2-one was then alkylated with (S)-glycidol as in Example 1H to yield 1-(4-(1-acetyl-4-[4-(2,3-dihydroxypropoxy)-3-methylphenyl]-piperidin-4-yl}-2-methylphenoxy)-3,3-dimethylbutan-2-one.

WORKUP

后处理

customwas prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5254087fae8e4c8fbde357d42b4b127c
来源数据集: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07863298B2
来源说明: uspto-grants-2011_01

反应 SMILES

[C:1]([N:4]1[CH2:9][CH2:8][C:7]([C:18]2[CH:31]=[CH:30][C:21]([O:22][CH2:23][C:24](=[O:29])[C:25]([CH3:28])([CH3:27])[CH3:26])=[C:20]([CH3:32])[CH:19]=2)([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[C:12]([CH3:17])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].ClCC(=O)C(C)(C)C.C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:47]1[O:49][C@H:48]1[CH2:50][OH:51]>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]([C:18]2[CH:31]=[CH:30][C:21]([O:22][CH2:23][C:24](=[O:29])[C:25]([CH3:26])([CH3:27])[CH3:28])=[C:20]([CH3:32])[CH:19]=2)([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:47][CH:48]([OH:49])[CH2:50][OH:51])=[C:12]([CH3:17])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]