反应详情

2-[(7-Methoxy-indol-1-yl)-pyridin-3-yl-methyl]-malonic acid tert-butyl ester methyl ester (0.200 g) was dissolved in toluene (50 ml) and treated with p-toluenesulfonic acid (0.102 g). The mixture was brought to reflux temperature and stirred for 4 hours. The reaction mixture was partitioned between ethyl acetate and aqueous bicarbonate solution, the organic layer was dried over magnesium sulfate, filtered and evaporated to dryness to afford 3-(7-methoxy-indol-1-yl)-3-pyridin-3-yl-propan-1-ol as an oil which was purified by column chromatography (ethyl acetate-hexane 3:7).

1. temperatureto reflux temperature
2. customThe reaction mixture was partitioned between ethyl acetate and aqueous bicarbonate solution
3. dry with materialthe organic layer was dried over magnesium sulfate
4. filtrationfiltered
5. customevaporated to dryness