2-(4-Methoxy-2-methyl-phenyl)-benzo[b]thiophene-7-carboxylic acid methyl ester → 2-(4-Hydroxy-2-methyl-phenyl)-benzo[b]thiophene-7-carboxylic acid methyl ester

HRID 250247Notes

Reaction equation

HRID 250247 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]2[S:11][C:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][C:15]=3[CH3:22])=[CH:13][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4]>CO>[CH3:1][O:2][C:3]([C:5]1[C:10]2[S:11][C:12]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][C:15]=3[CH3:22])=[CH:13][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 1

HCID 672719212-(4-Methoxy-2-methyl-phenyl)-benzo[b]thiophene-7-carboxylic acid methyl ester

Product 1

HCID 672725142-(4-Hydroxy-2-methyl-phenyl)-benzo[b]thiophene-7-carboxylic acid methyl esterYield 69%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound (85 mg, 69%) is prepared essentially as described in the synthesis of 2-(4-Hydroxy-2-methyl-phenyl)-benzo[h]thiophene-5-carboxylic acid ethyl ester, utilizing 2-(4-Methoxy-2-methyl-phenyl)-benzo[b]thiophene-7-carboxylic acid methyl ester and methanol. ES/MS m/e 297 (M−1).

Sources & evidence

ORD record
ord-d998b5b7f64146f8bbabdf1a57f4ee4f
Source dataset
uspto-grants-2011_01
Patent number
US07863302B2

Reaction notes

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