Hydrochloric Acid → 5-Acetyl-2-methoxybenzoic acid

HRID 25025Notes

Reaction equation

HRID 25025 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].Cl>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 606426Methyl 5-acetyl-2-methoxybenzoate

Product 1

HCID 189545915-Acetyl-2-methoxybenzoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Methyl 2-methoxy-5-acetylbenzoate (Step A, 3 g, 14.4 mmol) was dissolved in acetic acid (80 ml) and then treated with c HCl (28 ml). The reaction mixture was refluxed for 4 hours, concentrated under reduced pressure and lyophilized to provide the title compound as cream color solid, which was used without further purification.

Workup

  1. temperatureThe reaction mixture was refluxed for 4 hours
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b961f199bf5041a7a8304e2514b039a3
Source dataset
uspto-grants-2005_02
Patent number
US06858602B2

Reaction notes

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