反应详情

温度

85 °C

A solution of (4-bromo-2-nitro-phenyl)-acetic acid (5.00 g, 19.2 mmol) in methanol (100 mL) is treated with conc. HCl (1.0 mL). The mixture is stirred at 85° C. for 16 hours and cooled to room temperature. The mixture is neutralized with aqueous Na2CO3 and concentrated under reduced pressure. The residue is extracted with ethyl acetate (50 mL×2), and the combined organic layers are dried over sodium sulfate and concentrated under reduced pressure to provide the title compound (5.27 g, 100%) as a brown solid.

1. temperaturecooled to room temperature
2. concentrationconcentrated under reduced pressure
3. extractionThe residue is extracted with ethyl acetate (50 mL×2)
4. dry with materialthe combined organic layers are dried over sodium sulfate
5. concentrationconcentrated under reduced pressure