反应详情

A solution of 6-benzyloxy-benzofuran-2-carboxylic acid tert-butyl ester (5.68 g, 17.5 mmol) in THF (50 mL) and MeOH (20 mL) is added to Pd/C (5%, 200 mg). The mixture is stirred under a balloon of hydrogen for 16 hours at room temperature. The mixture is filtered through a pad of diatomaceous earth and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel chromatography eluting with 25% EtOAc/Hexanes to provide the title compound (3.99 g, 97%). LC-ES/MS m/e 233.0 (M−1).

1. filtrationThe mixture is filtered through a pad of diatomaceous earth
2. concentrationthe filtrate is concentrated under reduced pressure
3. customThe residue is purified by silica gel chromatography
4. washeluting with 25% EtOAc/Hexanes