反应详情

Potassium carbonate (57.8 g) was added to a solution mixture of 5-nitro-isoindole-1,3-dione (26.2 g) and bromo-acetic acid ethyl ester (25.1 g) in actone (500 ml). The resulting mixture was refluxed overnight (18 h). After cooling, reaction mixture was filtered and rinsed with ethyl acetate. Filtrate was concentrated and the residue was triturated with ether (200 ml). Solid was collected and rinsed with ether. Dried in vacuo to give the title compound 231.9 g. 1H NMR (200 MHz, CDCl3) δ 8.69 (m, 2H), 8.07 (d, J=8.2 Hz, 1H), 4.48 (s, 2H), 4.24 (q, J=7.0 Hz, 2H), 1.30 (t, J=7.0 Hz, 3H).

1. temperatureThe resulting mixture was refluxed overnight (18 h)
2. temperatureAfter cooling
3. customreaction mixture
4. filtrationwas filtered
5. washrinsed with ethyl acetate
6. concentrationFiltrate was concentrated
7. customthe residue was triturated with ether (200 ml)
8. customSolid was collected
9. washrinsed with ether
10. customDried in vacuo