Thionyl Chloride → HCID 58087452, compound

HRID 250571Notes

Reaction equation

HRID 250571 reaction equation
[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](O)=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3].S(Cl)([Cl:19])=O>>[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([Cl:19])=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 162282623-[(Propane-1-sulfonyl)amino]benzoic acid

Product 1

HCID 58087452HCID 58087452, compound

Procedure

A solution of 3-(propane-1-sulfonylamino)-benzoic acid (76, 1.20 g, 4.93 mmol) in thionyl chloride was heated to reflux for 3.0 hours. Evaporation of the solvent gave compound 77 as white solid that was used for the next step.

Workup

  1. temperatureto reflux for 3.0 hours
  2. customEvaporation of the solvent

Sources & evidence

ORD record
ord-5e4920dd7bd545bf8e68f5ef11f5b345
Source dataset
uspto-grants-2011_01
Patent number
US07863288B2

Reaction notes

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