Methanol → HCID 58086875, compound

HRID 250615Notes

Reaction equation

HRID 250615 reaction equation
[OH-].[K+].[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[CH:5]=[CH:4]1.[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=[O:25])=[CH:22][C:21]=1[O:28][CH3:29])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH3:30]O>>[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]([O:25][CH3:30])[C:5]2[C:6]3[C:11](=[N:10][CH:9]=[CH:8][CH:7]=3)[NH:3][CH:4]=2)=[CH:22][C:21]=1[O:28][CH3:29])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 14797Potassium HydroxideHCID 755064-(Benzyloxy)-3-methoxybenzaldehyde

Product 1

HCID 58086875HCID 58086875, compound

Procedure

Methanol (125 mL) and potassium hydroxide (4.4 g, 79 mmol) were mixed with 1H-pyrrolo[2,3-b]pyridine (94, 3.1 g, 26.6 mmol) and 4-benzyloxy-3-methoxy-benzaldehyde (564, 12.9 g, 53.2 mmol). The reaction was stirred at room temperature for 2 days. The resulting white solid was filtered and washed with water. Crude material was carried forward without further purification.

Workup

  1. filtrationThe resulting white solid was filtered
  2. washwashed with water
  3. customCrude material was carried forward without further purification

Sources & evidence

ORD record
ord-9ed37c67425f4cfea452a6070c51d516
Source dataset
uspto-grants-2011_01
Patent number
US07863288B2

Reaction notes

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