HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25067Generated: October 26, 2026
Ethyl bromopyruvate → (+/-)-7-(4-Ethoxycarbonyl-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
https://huagongshe.com/reaction/25067
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | (+/-)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine | HCID 12137394 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (+/-)-7-(4-Ethoxycarbonyl-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine | HCID 12137427 | 85% |
Reaction Steps
A mixture of 0.45 g (1.17 mmol) of the starting material I, 0.46 g (2.36 mmol) of ethyl bromopyruvate and 7 ml of dimethylformamide was stirred at 80° C. for 30 min. After cooling the precipitated crystals were filtered off, washed with ethanol and dried to yield 0.41 g (85%) of the title compound; Mp.: 242-243° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06858605B2 |
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| Source dataset | uspto-grants-2005_02 |
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| ORD ID | ord-3be6871f10994b319dc9c569ce143a0a |
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| Source note | uspto-grants-2005_02 |
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