Ammonium formate → N-[methoxy]-N-[methyl]3-cyclopentylamino-4-aminobenzamide

Participants

Reaction Conditions

Reaction Steps

Combine N-[methoxy]-N-[methyl]3-cyclopentylamino-4-nitrobenzamide (2.0 g, 6.82 mmol), ammonium formate (2.1 g, 34.1 mmol), and 0.36 g (3.41 mmol) Pd(C) in ethanol (25 mL). Heat the mixture to 60° C. and stir for two hours. Cool to room temperature and filter through a pad of celite. Concentrate the filtrate under reduced pressure to provide the desired compound (1.79 g).

Provenance & Evidence