Isobutylamine → HCID 86067101, compound

HRID 250732Notes

Reaction equation

HRID 250732 reaction equation
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[CH3:6][N:7]([O:20][CH3:21])[C:8](=[O:19])[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[C:11](F)[CH:10]=1>C(#N)C>[CH3:6][N:7]([O:20][CH3:21])[C:8](=[O:19])[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[C:11]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])[CH:10]=1

Participants

4

Reactant 2

HCID 6558IsobutylamineHCID 57758083HCID 57758083, compound

Product 1

HCID 86067101HCID 86067101, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Add isobutylamine (8.7 mL) dropwise to a solution of N-[methyl]-N-[methoxy]-3-fluoro-4-nitrobenzamide (2 g, 8.77 mmol) in 80 mL dry acetonitrile at 0° C. Stir the resulting orange solution at room temperature over night. Concentrate under reduced pressure to provide the desired compound (90%).

Workup

  1. concentrationConcentrate under reduced pressure

Sources & evidence

ORD record
ord-c86c433a2cee4afc9150c90fcaf4ff36
Source dataset
uspto-grants-2011_01
Patent number
US07863310B2

Reaction notes

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