Hydrochloric Acid → HCID 22565488, compound

HRID 25078Notes

Reaction equation

HRID 25078 reaction equation
[CH3:1][CH:2]1[CH2:8][C:7]2[CH:9]=[C:10]3[O:15][CH2:14][O:13][C:11]3=[CH:12][C:6]=2[C:5]([C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)=[N:4][N:3]1[C:25]([NH:27][NH:28][C:29](NC)=[O:30])=[S:26].Cl>>[CH3:1][CH:2]1[CH2:8][C:7]2[CH:9]=[C:10]3[O:15][CH2:14][O:13][C:11]3=[CH:12][C:6]=2[C:5]([C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)=[N:4][N:3]1[C:25]1[S:26][C:29](=[O:30])[NH:28][N:27]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86593812HCID 86593812, compound

Product 1

HCID 22565488HCID 22565488, compoundYield 70.2%

Conditions

Temperature
80 °C

Procedure

A mixture of 2.14 g (4.69 mmol) of the starting material XXX and 122 ml of concentrated hydrochloric acid was stirred at 80° C. A solid material precipitated from the starting solution. The reaction mixture was concentrated to about half of its volume, diluted with 40 ml of water and made alkaline with sodium hydrogen carbonate solution. The precipitated product was filtered off and washed with water to yield 1.40 g (70%) of the title compound. Mp.: 288° C.

Workup

  1. customA solid material precipitated from the starting solution
  2. concentrationThe reaction mixture was concentrated to about half of its volume
  3. additiondiluted with 40 ml of water
  4. filtrationThe precipitated product was filtered off
  5. washwashed with water

Sources & evidence

ORD record
ord-5b8ce4546a4746148a23e272d83e3803
Source dataset
uspto-grants-2005_02
Patent number
US06858605B2

Reaction notes

Loading…