反应详情

温度

110 °C

A mixture of 1.50 g (3.91 mmol) of the starting material XXIV and 15 ml of triethyl orthoformate in the presence of 0.05 ml of 36% hydrochloric acid was stirred at 110° C. for 30 min, then concentrated in vacuum. The residue was stirred with water, the precipitated crystals were filtered off, washed with water and recrystallized from 2-methoxyethanol to yield 1.15 g (75%) of the title compound; Mp.: 190-196° C.

1. concentrationconcentrated in vacuum
2. stirringThe residue was stirred with water
3. filtrationthe precipitated crystals were filtered off
4. washwashed with water
5. customrecrystallized from 2-methoxyethanol