反应详情

温度

60 °C

1.18 g (54 mmol, 3 eq) of lithium borohydride are added to a solution of 6.9 g of methyl 3-benzyloxy-4-iodobenzoate in 30 ml of tetrahydrofuran. The reaction medium is heated at 60° C. for 12 hours and then hydrolyzed with ammonium chloride solution and extracted with ethyl acetate. The organic phases are combined and the solvents are evaporated off. 6.5 g of (3-benzyloxy-4-iodophenyl)methanol in oil form are used in the following reaction without further purification.

1. extractionhydrolyzed with ammonium chloride solution and extracted with ethyl acetate
2. customthe solvents are evaporated off
3. custom6.5 g of (3-benzyloxy-4-iodophenyl)methanol in oil form are used in the following reaction without further purification