反应详情

A solution of 400 mg (0.98 mmol, 1 eq) of (E)-3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]acrylic acid (prepared in Example 27 g) in 10 mL of ethyl acetate in the presence of 0.2 ml of methanol is stirred for 4 hours at room temperature in the presence of 200 mg (50% by mass) of 10% palladium-on-charcoal under a hydrogen atmosphere. The reaction medium is filtered through Celite and then evaporated to dryness. After crystallization from ethyl ether/pentane, 265 mg of 3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]propanoic acid are obtained in the form of a white powder (m.p.=70° C.). Yield=66%

1. filtrationThe reaction medium is filtered through Celite
2. customevaporated to dryness
3. customAfter crystallization from ethyl ether/pentane, 265 mg of 3-[3′-(1-ethyl-3-heptylureido)biphenyl-4-yl]propanoic acid