tert-Butyl (3-aminopropyl)carbamate → HCID 67271831, compound

HRID 251045Notes

Reaction equation

HRID 251045 reaction equation
[C:1]([O:5][C:6](=[O:12])[NH:7][CH2:8][CH2:9][CH2:10][NH2:11])([CH3:4])([CH3:3])[CH3:2].[CH3:13][C:14]1[C:15]([CH:21]=O)=[N:16][CH:17]=[C:18]([CH3:20])[CH:19]=1.[BH4-].[Na+]>CO>[C:1]([O:5][C:6](=[O:12])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:21][C:15]1[C:14]([CH3:13])=[CH:19][C:18]([CH3:20])=[CH:17][N:16]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 2735700tert-Butyl (3-aminopropyl)carbamateHCID 4311764Sodium borohydrideHCID 187316833,5-Dimethylpyridine-2-carbaldehyde

Product 1

HCID 67271831HCID 67271831, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure B: Reaction of (3-aminopropyl)-carbamic acid tert-butyl ester and 3,5-dimethylpyridine-2-carboxaldehyde in anhydrous MeOH with NaBH4 gave {3-[(3,5-dimethyl-pyridin-2-ylmethyl)-amino]-propyl}-carbamic acid tert-butyl ester as a brown oil.

Sources & evidence

ORD record
ord-c4658868c12a4c62af61ffe28acf8d17
Source dataset
uspto-grants-2011_01
Patent number
US07863293B2

Reaction notes

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