Methanesulfonyl chloride → Methanesulfonic acid 4-(2,4-dimethoxyphenyl)butyl ester

HRID 25109Notes

Reaction equation

HRID 25109 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH2:11][CH2:12][CH2:13][CH2:14][OH:15].[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C(N(CC)CC)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH2:11][CH2:12][CH2:13][CH2:14][O:15][S:17]([CH3:16])(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 225661304-(2,4-Dimethoxyphenyl)butan-1-OL

Product 1

HCID 86589939Methanesulfonic acid 4-(2,4-dimethoxyphenyl)butyl esterYield 80%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Ester 77 was prepared by typical procedure E from alcohol 76 (4.15 g, 0.021 mol), methanesulfonyl chloride (2.4 mL, 0.03 mol) and triethylamine (20 mL). Crude 77 (4.6 g, 80%) was isolated as a yellow oil

Sources & evidence

ORD record
ord-f2cf5436ace84a088a9a260960aed484
Source dataset
uspto-grants-2005_02
Patent number
US06858614B2

Reaction notes

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