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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 251117Generated: October 26, 2026

1-(Pyridin-2-yl)ethan-1-amine → tert-Butyl 4-((1-(pyridin-2-yl)ethyl)amino)piperidine-1-carboxylate

https://huagongshe.com/reaction/251117

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Pyridin-2-yl)ethan-1-amineHCID 541877—
Reactanttert-Butyl 4-oxopiperidine-1-carboxylateHCID 735900—
ReactantSodium triacetoxyborohydrideHCID 5049666—
SolventDichloromethaneHCID 6344—
Producttert-Butyl 4-((1-(pyridin-2-yl)ethyl)amino)piperidine-1-carboxylateHCID 60137113—

Reaction Steps

Using General Procedure B: Reaction of 1-Pyridin-2-yl-ethylamine and 1-Boc-4-piperidone with NaBH(OAc)3 in CH2Cl2 gave 4-(1-Pyridin-2-yl-ethylamino)-piperidine-1-carboxylic acid tert-butyl ester as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07863293B2
Source datasetuspto-grants-2011_01
ORD IDord-dab1d5a7bdf04483bbff39ba6beb4e2d
Source noteuspto-grants-2011_01