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HRID251122

反应详情

EQUATION

反应方程式

HRID 251122 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：CC(C)c1cccnc1C=O
HCID45083635

3-(1-Methylethyl)-2-pyridinecarboxaldehyde

C9H11NO

结构：Cc1cc(Cl)cnc1CNC1CCN(C(=O)OC(C)(C)C)CC1
HCID67271827

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(Cl)cnc1CN(Cc1ncccc1C(C)C)C1CCN(C(=O)OC(C)(C)C)CC1
HCID67273014

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Using General Procedure B: Reaction of 4-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester and 3-Isopropyl-pyridine-2-carbaldehyde with NaBH(OAc)3 in CH2Cl2 gave 4-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-(3-isopropyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester as a white solid. Deprotection with TFA using General Procedure F gave (5-Chloro-3-methyl-pyridin-2-ylmethyl)-(3-isopropyl-pyridin-2-ylmethyl)-piperidin-4-yl-amine as a colorless oil.