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HRID251173

反应详情

EQUATION

反应方程式

HRID 251173 的结构方程式

REACTANTS

反应物

3
结构：Cc1cccnc1CN
HCID1514370

(3-Methylpyridin-2-yl)methanamine

C7H10N2

结构：CC(C)(C)OC(=O)N1CCC(C=O)CC1
HCID1514430

tert-Butyl 4-formylpiperidine-1-carboxylate

C11H19NO3

结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

PRODUCTS

生成物

1
结构：Cc1cccnc1CNCC1CCN(C(=O)OC(C)(C)C)CC1
HCID67271751

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Using General Procedure B, reaction of 4-formylpiperidine-1-carboxylic acid tert-butyl ester (Bioorg. Med. Chem. Lett. 2002, 12, 1785-1790), C-(3-methylpyridin-2-yl)-methylamine and NaBH(OAc)3 in CH2Cl2 gave 4-{[(3-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester as a clear oil.