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HRID251215

反应详情

EQUATION

反应方程式

HRID 251215 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：Cc1cnc(C=O)c(C)c1
HCID18731683

3,5-Dimethylpyridine-2-carbaldehyde

C8H9NO

结构：CC(C)(C)OC(=O)N1CCC(NC2CCCc3cccnc32)CC1
HCID67272553

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cnc(CN(C2CCN(C(=O)OC(C)(C)C)CC2)C2CCCc3cccnc32)c(C)c1
HCID67272426

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Using General Procedure B: Reaction of 4-(5,6,7,8-Tetrahydro-quinolin-8-ylamino)-piperidine-1-carboxylic acid tert-butyl ester and 3,5-dimethyl-pyridine-2-carbaldehyde with NaBH(OAc)3 in CH2Cl2 gave 4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amino]-piperidine-1-carboxylic acid tert-butyl ester as a white solid. Deprotection with TFA using General Procedure F gave (3,5-dimethyl-pyridin-2-ylmethyl)-piperidin-4-yl-(5,6,7,8-tetrahydro-quinolin-8-yl)-amine as a yellow oil.