HRID251257

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID67271653

未命名化合物

结构：CC(NCc1nc2ccccc2n1COCC[Si](C)(C)C)c1ccccn1

HCID67272285

未命名化合物

PRODUCTS

生成物

结构：CC(c1ccccn1)N(Cc1cscc1CN1C(=O)c2ccccc2C1=O)Cc1nc2ccccc2n1COCC[Si](C)(C)C

HCID67272671

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Using General Procedure A: Reaction of 2-(4-bromomethyl-thiophen-3-ylmethyl)-isoindole-1,3-dione, (1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amine, DIPEA and KI in CH3CN gave 2-[4-({(1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amino}-methyl)-thiophen-3-ylmethyl]-isoindole-1,3-dione.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6e3a264953674cc5bc1c02a188b6beb8
来源数据集: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07863293B2
来源说明: uspto-grants-2011_01

反应 SMILES

Br[CH2:2][C:3]1[C:4]([CH2:8][N:9]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]2=[O:19])=[CH:5][S:6][CH:7]=1.[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH:26]([NH:28][CH2:29][C:30]1[N:34]([CH2:35][O:36][CH2:37][CH2:38][Si:39]([CH3:42])([CH3:41])[CH3:40])[C:33]2[CH:43]=[CH:44][CH:45]=[CH:46][C:32]=2[N:31]=1)[CH3:27].CCN(C(C)C)C(C)C>CC#N>[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH:26]([N:28]([CH2:2][C:3]1[C:4]([CH2:8][N:9]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]2=[O:19])=[CH:5][S:6][CH:7]=1)[CH2:29][C:30]1[N:34]([CH2:35][O:36][CH2:37][CH2:38][Si:39]([CH3:40])([CH3:41])[CH3:42])[C:33]2[CH:43]=[CH:44][CH:45]=[CH:46][C:32]=2[N:31]=1)[CH3:27]