Sodium borohydride → HCID 67485876, compound

HRID 251308Notes

Reaction equation

HRID 251308 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH:8]=[O:9])[CH:5]=[C:4]([CH3:10])[C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1.[BH4-].[Na+]>CO.C(OCC)(=O)C>[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([CH3:10])[C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:20])[F:19])=[CH:13][CH:12]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 860853062,6-Dimethyl-4'-trifluoromethyl-biphenyl-4-carbaldehyde

Product 1

HCID 67485876HCID 67485876, compoundYield 82.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To the solution of 2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-carbaldehyde (3.0 g, 10.8 mmol) in MeOH (20 ml) is added NaBH4 (410 mg, 10.8 mmol). The mixture is stirred at room temperature for about 2 h, diluted with ethyl acetate, washed with 1N HCl, water, brine, dried over MgSO4, and concentrated to afford 2.5 g of the titled compound as a white solid. 1H-NMR.

Workup

  1. washwashed with 1N HCl, water, brine
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-7ac35139911a45c99bd9da7d99be2f56
Source dataset
uspto-grants-2011_01
Patent number
US07863329B2

Reaction notes

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