Dimethylformamide → HCID 135991194, compound

HRID 251387Notes

Reaction equation

HRID 251387 reaction equation
[CH2:1]([C:6]1[CH:17]=[C:10]2[C:11]([O:13][C:14](=O)[NH:15][C:9]2=[CH:8][CH:7]=1)=O)[CH2:2][CH2:3][CH2:4][CH3:5].[CH2:18]([C:23]1[CH:31]=[C:27](C(N)=O)[C:26]([OH:32])=[CH:25][CH:24]=1)[CH2:19][CH2:20][CH2:21][CH3:22].C[N:34](C=O)C>>[OH:32][C:26]1[CH:25]=[CH:24][C:23]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:31][C:27]=1[C:14]1[NH:34][C:11](=[O:13])[C:10]2[C:9](=[CH:8][CH:7]=[C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH:17]=2)[N:15]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 58089218HCID 58089218, compoundHCID 58089233HCID 58089233, compound

Product 1

HCID 135991194HCID 135991194, compound

Procedure

2.81 g compound 16 (12.1 mmole) and 2.50 g (112.1 mmole) compound 20 were heated at 150° C. in 10 ml DMF for 3.5 h. The mixture was slowly cooled down to room temperature, the formed crystals were isolated by filtration and washed with 3 ml MeOH. After drying, 2 g of compound 21 was obtained as pale green crystals (43% yield).

Workup

  1. customthe formed crystals were isolated by filtration
  2. washwashed with 3 ml MeOH
  3. customAfter drying

Sources & evidence

ORD record
ord-3d9763db7c954d2da70be9a89cf76708
Source dataset
uspto-grants-2011_01
Patent number
US07863428B2

Reaction notes

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