反应详情

piperazine (1.23 g, 14.32 mmol) was treated with 6-chloro-2,4-dimethoxy pyrimidine (0.5 g, 2.86 mmol) in acetonitrile (5 mL) and the reaction mixture was stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
2. extractionextracted with ethyl acetate (25 ml)
3. washThe organic layer was washed with aqueous sodium bicarbonate solution
4. customevaporated